Scott Rudin is producing the project and it will be based on the book "Cleopatra: A Life" by Stacy Schiff. James Cameron and Paul Greengrass had both been rumored to directed but now both are busy with other projects. Cameron is directing "Avatar 2" and "Avatar 3" next, while Greengrass is making "Memphis", a film about the Martin Luther King Jr. assassination. Now, it looks like Scott Rudin wants David Fincher to direct the film. Fincher, currently filming the English language adaptation of "The Girl With the Dragon Tattoo", may not be able to direct "Cleopatra" even if he is interested. Fincher will likely direct the English language adaptation of "The Girl Who Played With Fire" (the sequel to "The Girl With the Dragon Tattoo").
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